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Replica experiments with dipyridamole in mice, rabbits, and rats have uncovered no proof of damage to the fetus around doses about 25 instances the utmost suggested everyday human dose of aspirin-dipyridamole.
In extreme situations, hyperthermia and hypovolemia are the main instant threats to life. Plasma concentrations of aspirin earlier mentioned 300 μg/mL are Evidently poisonous. Extreme harmful results are affiliated with concentrations previously mentioned 400 μg/mL. Only one lethal dose of aspirin in adults is not really recognised with certainty but Loss of life could possibly be envisioned at thirty g.
As a result of oblique impact of aspirin on the renin-angiotensin conversion pathway, the hyponatremic and hypotensive effects of ACE inhibitors may be diminished by concomitant administration of aspirin.
Aspirin, on your own, induced chromosome aberrations in cultured human fibroblasts. Mutagenicity tests of dipyridamole by yourself with bacterial and mammalian cell systems were negative.